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DBPR108, A Dipeptidyl Peptidase-4 Inhibitor for Treatment of Type 2 Diabetes Mellitus: A Phase I, Randomized, Double-Blind, Placebo-Controlled Trial of Single and Multiple Doses in Healthy Volunteers

1. Abstract 1.1. Aims DBPR108 is an orally active dipeptidyl peptidase 4 (DPP-4) inhibitor in animals. The present first-in-human randomized, double-blind, and placebo-controlled study evaluated DBPR108 for safety and tolerability in healthy adult Asian male volunteers. 1.2. Main Methods DBPR108 were orally given at 25-600 mg as single and multiple once-daily doses for 8 consecutive …

DBPR108, A Dipeptidyl Peptidase-4 Inhibitor for Treatment of Type 2 Diabetes Mellitus: A Phase I, Randomized, Double-Blind, Placebo-Controlled Trial of Single and Multiple Doses in Healthy Volunteers Read More »

Partial Splenic Embolization for the Treatment of Thrombocytopenia in Cancer Patients

1. Abstract Thrombocytopenia is a common sequela of chemotherapy treatment of many non-hematologic malignancies. Severe thrombocytopenia may necessitate halting chemotherapy or lead to hemorrhagic complications that impact patient morbidity and mortality. Partial Splenic Embolization (PSE) has been shown to be effective at improving platelet counts in appropriately selected patients and allowing for the resumption of …

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Management of Hyperacute Rejection during Operation in Living Donor Liver Transplantation – A Case Report

1. Abstract Hyperacute rejection in solid organ transplantation is a catastrophic event and leads to graft failure immediately. It rarely happens in liver transplantation during operation. A 58-year-old male patient had salvage living donor liver transplantation for recurrent hepatocellular carcinoma. His wife was the donor. All the transplantation procedures were uneventful until bile duct anastomosis …

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Identification of Pyroptosis-Related Subtypes in Liver Cancer, Establishment of Prognostic Models, and Characterization of Tumor Microenvironment Infiltration

1. Abstract 1.1. Objectives: Pyroptosis is a type of programmed cell death that has been discovered and confirmed in recent years, which were characterized by pro-inflammatory and is related to tumor progression, prognosis and treatment response. However, the potential roles of pyroptosis-related genes (PRGs) in the tumor microenvironment (TME) remain unclear. At the same time, …

Identification of Pyroptosis-Related Subtypes in Liver Cancer, Establishment of Prognostic Models, and Characterization of Tumor Microenvironment Infiltration Read More »

Clinical Relevance of Bile Acid and their Conjugates in Health and Disease

1. Short Communication Bile Acids (BA) are synthesized by the oxidation of cholesterol in the liver and secreted into the duodenum. BAs were circulated from the duodenum back to the liver by enterohepatic recirculation. BAs regulate many physiological functions, including the expression of genes involved cholesterol, glucose, and their homeostasis. BAs have several pathologic effects, …

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Comparative Efficacy and Safety of Polyethylene Glycol vs Lactulose in Chronic Constipation: Non Inferiority Study

1. Abstract 1.1. Background: Constipation is a common condition. Lactulose & Polyethylene Glycol (PEG) are effective & safe, recommended as first-line medication for Chronic Constipation (CC). 1.2. Aim: To compare the efficacy and safety of PEG 3350 versus lactulose in patients with CC. 1.3. Methods: In this single-center, randomised, open label, parallel-group study. Patients with …

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Pulmonary Pleura Metastasis from Low-Grade Appendiceal Mucinous Neoplasm with Appendiceal Neuroendocrine Tumor: A Case Report and Literature Review

1. Abstract Low-grade Mucinous Appendiceal Neoplasm (LAMN) is a rare appendiceal tumor and has low malignant potential. LAMN and Appendiceal Neuroendocrine Tumor (ANET) are the most frequent benign and malignant appendiceal lesions. A collision between LAMN and Appendiceal neuroendocrine tumor (ANET)is an exceedingly rare condition. So far, evaluating the literature, just 10 cases of collision …

Pulmonary Pleura Metastasis from Low-Grade Appendiceal Mucinous Neoplasm with Appendiceal Neuroendocrine Tumor: A Case Report and Literature Review Read More »

Upper Limit of Normal Serum Alanine Transaminase ALT and Correlation with Gender and BMI

1. Abstract Alanine transaminase ALT is considered the most specific marker for hepatocellular membrane damage, once asymptomatic ALT elevation may be the only indicator of some liver diseases such as non-alcoholic fatty liver disease NAFLD which is the most common liver disease in the western world, so it is necessary to define upper limit of …

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Identification of Polyamine Subtypes in Hepatocellular Carcinoma and Characteristics of their Immune Infiltrates

1. Abstract 1.1. Background: Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related death. Due to the poor prognosis of standard treatment, it is urgent to evaluate the immune molecular characteristics and find new HCC immune biomarkers and immunotherapy . The homeostasis of polyamines is closely related to tumor progression and prognosis. The …

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