Volume 5

Vedolizumab-Related Arthralgias in Patients with Inflammatory Bowel Disease: A Systematic Review

1. Abstract 1.1 Background: Multiple papers have reported the development of new-onset arthralgias with vedolizumab (VDZ) for the treatment of Inflammatory Bowel Disease (IBD). Other studies have shown that VDZ may help in preexisting enteropathic spondyloarthropathy. We sought to probe this issue by conducting a systematic review. DOI:http://dx.doi.org/10.47829/JJGH.2021.51103

Abnormal Indicators of Autoantibodies and Liver Fibrosis in Patients with Covid-19

1. Abstract The authors describe a 48-year-old man with Covid-19 diagnosed in January 2020 in Huangshi, Hubei Province in China, along with two other critically ill patients with Covid-19 who were also seen in the same intensive care unit. Mild liver dysfunction combined with abnormal indicators of liver fibrosis and autoantibodies were seen in all …

Abnormal Indicators of Autoantibodies and Liver Fibrosis in Patients with Covid-19 Read More »

Joubert Syndrome: When to Suspect a Ciliopathy in a Patient with Liver Failure and Syndromic Phenotype

1. Abstract Joubert Syndrome (JS) and related disorders (JSRD) are a group of rare and heterogeneous conditions that share as a hallmark the “molar tooth sign” (MTS), a complex midbrain-hindbrain malformation visible on brain imaging. Ten causative genes with different patterns of inheritance have been identified to date, all encoding for proteins of the primary …

Joubert Syndrome: When to Suspect a Ciliopathy in a Patient with Liver Failure and Syndromic Phenotype Read More »

Reactive and Extreme Thrombocytosis After the First Infusion of Vedolizumab in an Ibd Patient

1. Abstract We report a case of reactive and extreme thrombocytosis in an inflammatory bowel disease patient after receiving the first infusion of Vedolizumab (VDZ). To the best of our knowledge, VDZ does not have this adverse reaction, and this possible association has not been described in the literature. DOI:http://dx.doi.org/10.47829/JJGH.2021.51005

Secondary Signs Related to Pancreatic Adenocarcinomas on CT: Are They Really Specific Findings for Malignancies?

1. Abstract 1.1. Introduction: This study aimed to investigate whether pancreatic secondary signs on contrast-enhanced dynamic CT are really specific for patients with pancreatic adenocarcinomas. 1.2. Methods: A retrospective review of dynamic CT findings was performed for 93 patients with suspected pancreatic adenocarcinomas and with any secondary CT signs. Among these 93 patients with secondary …

Secondary Signs Related to Pancreatic Adenocarcinomas on CT: Are They Really Specific Findings for Malignancies? Read More »

Hepatitis B e Antigen Synthesis is Inhibited by a Galactosylated Arginine-Rich Macromolecule Via Asialoglycoprotein Receptor

1. Abstract 1.1. Aims: The poor prognoses of hepatitis B virus (HBV) infection are correlated with hepatitis B e antigen (HBeAg). Current antiviral therapy does not directly interfere with HBeAg synthesis. HBeAg formation depends on proprotein convertase furin. To block HBeAg synthesis on purpose, galactosylated arginine-rich macromolecular furin inhibitors were developed and evaluated. DOI:http://dx.doi.org/10.47829/JJGH.2021.51002

Resection of Fourth Segment of Liver as a Cause of Hepatoblastoma in A 8 Month- Old-Boy

1. Abstract Intraductal papillary neoplasia of the bile ducts (IPN-B) is a rare intracanal tumor characterized by papillary proliferation of the biliary epithelium responsible for more or less abundant production of mucus, causing dilation of the duct [1]. IPN-B is the “biliary” equivalent of TIPMP. MRI cholangiography and transcutaneous abdominal ultrasound are the best examinations …

Resection of Fourth Segment of Liver as a Cause of Hepatoblastoma in A 8 Month- Old-Boy Read More »

Unexpected Esophageal Mucosal Defects After Peroral Endoscopic Myotomy (POEM)

1. Abstract Intraductal papillary neoplasia of the bile ducts (IPN-B) is a rare intracanal tumor characterized by papillary proliferation of the biliary epithelium responsible for more or less abundant production of mucus, causing dilation of the duct [1]. IPN-B is the “biliary” equivalent of TIPMP. MRI cholangiography and transcutaneous abdominal ultrasound are the best examinations …

Unexpected Esophageal Mucosal Defects After Peroral Endoscopic Myotomy (POEM) Read More »