Volume 8

Involvement of Claudin-1 in Thrombin Promoting Airway Remodeling in Asthma

1. Abstract Claudin-1 is an important member of the cellular tight junction protein, which is very important to barrier function. But some studies have shown that Claudin-1 is associated with cell proliferation, so its role in asthma gets more and more attention. Asthma is associated with clotting system in the lungs. Thrombin is thought to …

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Rarely Seen Duodenal Varices Merit Vigilant Endoscopy

1. Abstract 1.1. Case Report: We present a thirty year old female who was diagnosed recently to be suffering from cryptogenic related compensated chronic liver disease. She had no history of ascites, pedal edema, upper or lower gastrointestinal bleed or Porto systemic encephalopathy. On evaluation her complete haemogram revealed mild anemia and thrombocytopenia, liver function …

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NAFLD Patients have Limited Access to GLP1 Agonists and SGLT2 Inhibitors: NHANES-Transient Elastography 2017-2018

1. Abstract 1.1. Background and Aims: This study analyzed medications among NAFLD (controlled attenuation parameter ≥302 dB/m) ± diabetes or advanced fibrosis (AF, stiffness ≥9.7 kPa). 1.2. Method: 2017-2018 NHANES data were analyzed. Exclusion criteria were age<18, high alcohol consumption (≥7/14 drinks/week for females/males, respectively), or viral hepatitis. 1.3. Results: Of 3,899, 26.3% had NAFLD, …

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Changes of Plasma Biomarkers in Patients with Chronic Liver Diseases Predict Liver Cell Death

1. Abstract 1.1. Background: We evaluated the changes of biomarkers and their significance in patients with nonalcoholic fatty liver disease. 1.2. Methods: One hundred and ten nonalcoholic fatty liver disease patients were enrolled into experimental group and one hundred and ten healthy people into control group. The plasma levels of biomarkers were detected. 1.3. Results: …

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Research Progress of Intestinal Flora and High Fat Diet Obesity

1. Abstract Obesity is a chronic metabolic disorder caused by an energy imbalance, which is becoming an increasingly prevalent and ubiquitous problem worldwide. Its cause is complex, including genetic factors, high fat diet, intestinal tract bacterium group. The effect of intestinal flora on obesity has been widely recognized in the past few years. This article …

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Endocuff-Assisted Colonoscopy Demonstrates High Ileal Intubation and Adenoma Detection Rates in Trainees

1. Abstract 1.1. Introduction: The Endocuff (EC) significantly improves the Adenoma Detection Rate (ADR). Whereas cecal intubation and cost-effectiveness using the EC have been studied repeatedly, evidence regarding the Ileum Intubation Rate (IIR) remains scarce. This study investigates the IRR and ADR in EC-assisted colonoscopy compared with standard colonoscopy in patients undergoing screening and/or surveillance …

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Primary Murine Hepatocyte Isolation and Culture with GMP and Research-Grade Enzyme Blends

1. Abstract Hepatocyte transplantation for acute liver failure and metabolic liver disorders represent a potential alternative to traditional orthotopic liver transplantation (OLT). Additionally, cultured primary hepatocytes are an important tool for in vitro pharmacological studies. Advances in clinical hepatocyte transplantation and drug studies depend on the development of standardized isolation and culturing protocols as well …

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Severe Hypothermia Due to Anorexia Nervosa

1. Abstract Anorexia nervosa is a mental disorder that approximately affect 0.5% to 1% of college-aged women, and the prevalence of this disorder is increasing. Acute hypothermia is a dramatic event that occasionally occur after prolonged cold exposure, generally after motor vehicle accidents, or after prolonged cold water immersion, or after prolonged exposure to cold …

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Multiple Hepatic and Osseous Focal Lesions without Splenomegaly and/or Lymph Nodes Enlargement

1. Abstract 1.1. Background: Hepatic involvement is a common extranodal manifestation of common and some rare hematologic malignancies. Although the imaging features of more common hepatic diseases such as hepatocellular carcinoma, metastases, and infection may overlap with those of hepatic hematologic malignancies, combining the imaging features with clinical manifestations and laboratory findings can facilitate correct …

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Acute Tumor Inflammation with CD4/8+ and CD11+ Enhanced Long Survival Time in Advanced Stages of all Solid tumors by Ultra Minimum Incision Personalized Intratumoral Chemoimmunotehrapy

1. Abstract 1.1. Aim: The objective of study reported here was to evaluate the clinical efficacy, side effects and long survival time in the advanced stages of all solid tumors after the treatment of UMIPIC. 1.2. Methods: 581 patients with solid tumors in late stages were collected for retrospect analysis of their clinical efficacy, adverse …

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