Issue 1 Articles

Comparable Outcomes of Uncovered Metallic Stents and Partially Covered Metallic Stents in Malignant Distal Duodenal Obstruction

1. Abstract 1.1. Background/Purpose: Endoscopic management with self-expandable metallic stents (SEMSs) for advanced malignant gastroduodenal obstruction is widely used, however stenting in patients with malignant distal duodenal obstruction (MDDO) is challenging because of the length and flexibility of the endoscope, the curved configuration of the duodenal C-loop, and the angle of the duodenojejunal flexure. Studies …

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Long-Term Follow-Up of Overdose of Iron Tablets in Adult Successfully Managed Without Liver Transplant: A Case Report

1. Abstract Iron toxicity is common in children because of accidental ingestion. However, there are very less reports of adults with suicidal attempts. We report a case of 19 years old who developed acute liver injury 48 hrs after the deliberate consumption of a large dose of iron tablets. Laboratory tests for other hepatotoxins were …

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Can combination of SGLT2 inhibitors and DPP-4 inhibitors be combination of choice for T2DM associated MAFLD?

1. Abstract Globally, metabolic associated fatty liver disease (MAFLD) is the leading cause of liver disease and the most common cause for liver transplantation. Type 2 Diabetes mellitus (T2DM) is major risk factor for development of MAFLD with Indian prevalence of 56.5% T2DM patients suffering from MAFLD. MAFLD and T2DM are pathophysiological linked with IR, …

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Split-dose Lactulose with Adjunctive Oral Bisacodyl and Oral Sodium Phosphate: A Pilot Study of a Novel Bowel Preparation

1. Abstract 1.1. Background: Various colonoscopic bowel preparations are in use clinically. Split-dose preparations are generally recommended for morning colonoscopies. We herein present a novel form of bowel preparation with split-dose lactulose as the backbone with oral bisacodyl and sodium phosphate, in a pilot study assessing its safety and efficacy.

Clinical Predictive Value of CD-DST for the Efficacy of Postoperative XELOX Adjuvant Chemotherapy in Advanced Gastric Adenocarcinoma

1. Abstract 1.1. Introduction: Anticancer drug insensitivity/resistance is a bottleneck in the treatment of gastric cancer. To overcome this challenge, we evaluated the clinical utility of an in-vitro collagen gel droplet embedded culture drug sensitivity test (CD-DST) using patient-derived gastric cancer tissues for personalized treatment guidance. 1.2. Methods: We collected the surgically removed fresh tumor …

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Appendicular Tuberculosis- A Rare Entity

1. Abstract 1.1. Background: Tubercular appendicitis is a rarely encountered entity, even in developing country like India where tuberculosis (TB) is highly prevalent. 1.2. Case Report: A 26-year-old female patient presented initially with short duration epigastric pain associated with intermittent vomiting and mimicked non ulcer dyspepsia (NUD). The pain later became more intense, generalized and …

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Tele Counseling -Effective Strategy for Blood Donors with Chronic Hepatitis B and C

1. Abstract 1.1. Background: The blood is a life saving component which cannot be produced but has to donated by healthy donors. In view of high Seroprevalence of transfusion-transmitted infectious diseases such as HIV, hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis in India which affects the safety of blood for recipients, mandatory …

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Application of Teach-back Health Education Model in Nutritional Support Manage- ment During Radiotherapy for Patients with Locally Advanced Esophageal Cancer

1. Abstract 1.1. Aim: To explore whether the teach-back health education model can reduce the incidence of malnutrition during radiotherapy in pa- tients with locally advanced esophageal cancer. 1.2. Methods: A historical study design was used to compare the in- cidence of malnutrition during radiotherapy between the traditional education model and the teach-back health education …

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Expression Mechanism of Immunogenic Cell Death-Related Molecules in Colorectal Cancer

1. Abstract Immunogenic Cell Death (ICD) plays an important role in the treatment of colorectal cancer, and the relevant molecular mechanisms of its role in colorectal cancer are closely related to a variety of Damage-Associated Molecular Patterns (DAMPs), such as calreticulin (CRT), Heat Shock Protein (HSP), Adenosine Triphosphate (ATP), high mobility group protein B1 (HMGB1) …

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Metadoxine Prevents Endoplasmic Reticulum Stress and Apoptosis in Mice and Patients with Non-Alcoholic Steatohepatitis

1. Abstract Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder. Although metadoxine successfully affects alcohol-associated steatohepatitis, its impact on non-alcoholic steatohepatitis (NASH) is mostly unknown. This study aims to explore the underlying mechanism of metadoxine and determine its impact and healing potential in NASH. We used and randomly divided male C57BL/6J mice …

Metadoxine Prevents Endoplasmic Reticulum Stress and Apoptosis in Mice and Patients with Non-Alcoholic Steatohepatitis Read More »