Research Article

Comparable Outcomes of Uncovered Metallic Stents and Partially Covered Metallic Stents in Malignant Distal Duodenal Obstruction

1. Abstract 1.1. Background/Purpose: Endoscopic management with self-expandable metallic stents (SEMSs) for advanced malignant gastroduodenal obstruction is widely used, however stenting in patients with malignant distal duodenal obstruction (MDDO) is challenging because of the length and flexibility of the endoscope, the curved configuration of the duodenal C-loop, and the angle of the duodenojejunal flexure. Studies …

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Clinical Predictive Value of CD-DST for the Efficacy of Postoperative XELOX Adjuvant Chemotherapy in Advanced Gastric Adenocarcinoma

1. Abstract 1.1. Introduction: Anticancer drug insensitivity/resistance is a bottleneck in the treatment of gastric cancer. To overcome this challenge, we evaluated the clinical utility of an in-vitro collagen gel droplet embedded culture drug sensitivity test (CD-DST) using patient-derived gastric cancer tissues for personalized treatment guidance. 1.2. Methods: We collected the surgically removed fresh tumor …

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Tele Counseling -Effective Strategy for Blood Donors with Chronic Hepatitis B and C

1. Abstract 1.1. Background: The blood is a life saving component which cannot be produced but has to donated by healthy donors. In view of high Seroprevalence of transfusion-transmitted infectious diseases such as HIV, hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis in India which affects the safety of blood for recipients, mandatory …

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Metadoxine Prevents Endoplasmic Reticulum Stress and Apoptosis in Mice and Patients with Non-Alcoholic Steatohepatitis

1. Abstract Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder. Although metadoxine successfully affects alcohol-associated steatohepatitis, its impact on non-alcoholic steatohepatitis (NASH) is mostly unknown. This study aims to explore the underlying mechanism of metadoxine and determine its impact and healing potential in NASH. We used and randomly divided male C57BL/6J mice …

Metadoxine Prevents Endoplasmic Reticulum Stress and Apoptosis in Mice and Patients with Non-Alcoholic Steatohepatitis Read More »

Epidemiology of Small Gastrointestinal Stromal Tumors and Survival Outcomes Due To Surgical Options: A SEER-Based Population Retrospective Study

1. Abstract 1.1. Background: There is a dearth of population-based evidence regarding the role of surgery in the treatment of patients with small gastrointestinal stromal tumors (sGISTs)(<2cm). The purpose of this study was to describe the demographic features and investigate the impact of surgery treatment on survival outcome in patients with sGISTs.

DBPR108, A Dipeptidyl Peptidase-4 Inhibitor for Treatment of Type 2 Diabetes Mellitus: A Phase I, Randomized, Double-Blind, Placebo-Controlled Trial of Single and Multiple Doses in Healthy Volunteers

1. Abstract 1.1. Aims DBPR108 is an orally active dipeptidyl peptidase 4 (DPP-4) inhibitor in animals. The present first-in-human randomized, double-blind, and placebo-controlled study evaluated DBPR108 for safety and tolerability in healthy adult Asian male volunteers. 1.2. Main Methods DBPR108 were orally given at 25-600 mg as single and multiple once-daily doses for 8 consecutive …

DBPR108, A Dipeptidyl Peptidase-4 Inhibitor for Treatment of Type 2 Diabetes Mellitus: A Phase I, Randomized, Double-Blind, Placebo-Controlled Trial of Single and Multiple Doses in Healthy Volunteers Read More »

Identification of Pyroptosis-Related Subtypes in Liver Cancer, Establishment of Prognostic Models, and Characterization of Tumor Microenvironment Infiltration

1. Abstract 1.1. Objectives: Pyroptosis is a type of programmed cell death that has been discovered and confirmed in recent years, which were characterized by pro-inflammatory and is related to tumor progression, prognosis and treatment response. However, the potential roles of pyroptosis-related genes (PRGs) in the tumor microenvironment (TME) remain unclear. At the same time, …

Identification of Pyroptosis-Related Subtypes in Liver Cancer, Establishment of Prognostic Models, and Characterization of Tumor Microenvironment Infiltration Read More »

Comparative Efficacy and Safety of Polyethylene Glycol vs Lactulose in Chronic Constipation: Non Inferiority Study

1. Abstract 1.1. Background: Constipation is a common condition. Lactulose & Polyethylene Glycol (PEG) are effective & safe, recommended as first-line medication for Chronic Constipation (CC). 1.2. Aim: To compare the efficacy and safety of PEG 3350 versus lactulose in patients with CC. 1.3. Methods: In this single-center, randomised, open label, parallel-group study. Patients with …

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Upper Limit of Normal Serum Alanine Transaminase ALT and Correlation with Gender and BMI

1. Abstract Alanine transaminase ALT is considered the most specific marker for hepatocellular membrane damage, once asymptomatic ALT elevation may be the only indicator of some liver diseases such as non-alcoholic fatty liver disease NAFLD which is the most common liver disease in the western world, so it is necessary to define upper limit of …

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Identification of Polyamine Subtypes in Hepatocellular Carcinoma and Characteristics of their Immune Infiltrates

1. Abstract 1.1. Background: Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related death. Due to the poor prognosis of standard treatment, it is urgent to evaluate the immune molecular characteristics and find new HCC immune biomarkers and immunotherapy . The homeostasis of polyamines is closely related to tumor progression and prognosis. The …

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