Research Article

Self-expandable Metallic Stents for the Palliation of Malignant Growth of Esophagus

1. Abstract 1.1. Background: Often patients with carcinomas of esophagus presents with dysphagia at a late stage where curative treatments are not a treatment option. To relieve dysphagia and its consequences palliative esophageal stentings are offered. Self-expanding metal stents (SEMS) and self-expanding plastic stents (SEPS) are available for reliving the dysphagia. Uncovered, partially covered, or …

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Effects of Targeting NRF2 on Inhibiting Gastric Cancer Growth and Tumor Development in Vitro and in Vivo

1. Abstract 1.1. Background: Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a transcription factor that regulates the expression of the cellular antioxidant response. Traditionally, Nrf2 is regarded as a tumor suppressor owing to its characteristic which prevents oxidative or electrophilic insult. However, there is increasing evidence that Nrf2 is activated in malignant cells. At …

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Network Meta-Analysis of Hepatic Arterial Infusion Versus Selective Internal Radiation Therapy for Colorectal Cancer Liver Metastasis

1. Abstract 1.1. Background: Colorectal cancer liver metastases (CRLM) that cannot be surgically removed are often addressed locally with Hepatic Arterial Infusion (HAI) or Selective Internal Radiation Therapy (SIRT). This study used Bayesian network meta-analysis (NMA) to assess the differences in survival between patients treated with HAI or SIRT for CRLM.

Determinants of the Outcome in Liver Cirrhosis Patients Admitted in Intensive Care Unit for Severe Sepsis or Septic Shock: An Unselected Cohort Study

1. Abstract 1.1. Introduction: Determinants of mortality of patients with liver cirrhosis and septic shock are poorly known. 1.2. Methods: Multicenter observational study including all patients with liver cirrhosis admitted in ICU for severe sepsis/septic shock in 1997-2014 from the OUTCOMEREA® database. Patients with liver transplantation were excluded. Risk factors of 28-day and 90-day mortality …

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Network Meta-Analysis of Hepatic Arterial Infusion Versus Selective Internal Radiation Therapy for Colorectal Cancer Liver Metastasis

1. Abstract 1.1. Background: Colorectal cancer liver metastases (CRLM) that cannot be surgically removed are often addressed locally with Hepatic Arterial Infusion (HAI) or Selective Internal Radiation Therapy (SIRT). This study used Bayesian network meta-analysis (NMA) to assess the differences in survival between patients treated with HAI or SIRT for CRLM.

Hepcidin, Ferroportin and Hephaestin Levels in Inflammatory Bowel Disease; Are they Key Mediators of Anemia or Inflammation?

1. Abstract 1.1. Background: Anemia represents a significant problem in Inflammatory Bowel Disease (IBD) and diagnosis may be challenging due to inflammation. Hepcidin, ferroportin and hephaestin are novel Iron Regulatory Proteins (IRPs) involved in iron metabolism. This study aimed to identify the interactions of these proteins in IBD patients, guiding safe iron supplementation and effective …

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High-Throughput Uplc-G2si-Hdms Based Discovery of the Effective Constituents of Yindan Pinggan Capsule Against Yang Huang Syndrome

1. Abstract 1.1. Background: Yindan Pinggan Capsule, a patent Chinese medicine, has a definite effect on Yang Huang syndrome. At present, the pharmacological activity and quality control of Yindan Pinggan Capsule have been studied, but its effective constituents on the treatment of Yang Huang syndrome are still unclear.