Research Article

Acute Tumor Inflammation with CD4/8+ and CD11+ Prolong The Survival Effect Induced by Intratumral Injection Optimum Combination of Chemotherapy Drugs with Hydralazine as Hapten in Animal Model

1. Abstract 1.1. Purpose To study the survival time of mice with tumor by intratumoral injection with chemotherapy drug Adr plus hapten of DNP or Hydra and find a combination of drugs of Adr with DNP or Hydra can prolong their life, and which one of DNP or Hydra can provide a long life extension …

Acute Tumor Inflammation with CD4/8+ and CD11+ Prolong The Survival Effect Induced by Intratumral Injection Optimum Combination of Chemotherapy Drugs with Hydralazine as Hapten in Animal Model Read More »

Association of IL-32 Isoforms Responses with Pegifn Therapy in Chronic HBV Infection

1. Abstract Interleukin-32 is a proinflammatory cytokine with immune protective effect. IL-32γ mediates antiviral activity of cytokines against HBV. However, the dynamic expression level of IL-32 isoforms in CHB and whether they are affected by drug therapy is not clear. Here we show that the persistent increased expression of plasma IL-32 is related to the …

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Health-Related Quality of Life Among Rural Chinese Patients with Upper Gastrointestinal Diseases at Different Pathological Stages: A Cross-Sectional Study

1. Abstract 1. Aims: This study aims to compare the HR-QoL among rural Chinese patients with upper GI diseases at different pathological stages and to determine the factors influencing HR-QoL in this population. 1.2. Methods: A cross-sectional survey was conducted in two counties in Shandong province in China from July to September 2018. Demographic and …

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Prevalence and Characterization of Hepatitis C infection and Determination of Liver Damage in Patients on Chronic Hemodialysis at the Largest Reference Center for Renal Health, EsSalud, Lima, Peru

1. Abstract 1.1. Background: Hepatitis C (HCV) is a serious public health problem with approximately 3% of the world’s population infected. Patients on chronic hemodialysis are known to be a population at risk of HCV infection worldwide. 1.2. Aims: This study aimed to estimate the serological prevalence of HCV and characterize the HCV viral load …

Prevalence and Characterization of Hepatitis C infection and Determination of Liver Damage in Patients on Chronic Hemodialysis at the Largest Reference Center for Renal Health, EsSalud, Lima, Peru Read More »

The Influence of Anaemia and Perioperative Blood Transfusion in The Outcomes of Gastric Cancer

1. Abstract 1.1. Background: Gastric cancer is often associated with anaemia, at the time of diagnosis, which may contribute to worse outcomes after surgery. This study aims to evaluate the impact of preoperative anaemia and the need of perioperative transfusions in surgical and oncological outcomes among patients undergoing gastric cancer surgery. 1.2. Methods: This single …

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Optimizing Comfort Through Vocal Amplification During Non-Invasive Ventilation in the Acute Settings: A Proof-of-Concept (POC) Study

1. Abstract 1.1. Introduction: Refusal of Non-Invasive Ventilation (NIV) in acute respiratory failure is associated with a worse prognosis. This study aimed to evaluate the impact of improving the subject’s verbal communication on comfort and frustration levels during NIV sessions. 1.2. Methods: Setting and design: Single-center, prospective, cross-over, randomized, double blind study. Population: NIV-naïve subjects …

Optimizing Comfort Through Vocal Amplification During Non-Invasive Ventilation in the Acute Settings: A Proof-of-Concept (POC) Study Read More »

Bacteria Influence on Testosterone Level

1. Abstract 1.1. Objective: We examined Lizate of Bacillus Lyuba, which was isolated from ancient permafrost, on human. 1.2. Method and materials: There were eighteen participants included in this study. All participants underwent daily taking of lizate of 109 bacterial cells, in 40% alcohol solution (about 2-4 ml) in the morning for one month. Two …

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Advancement in Colorectal Cancer (CRC) Treatment in The Past Two Decades: A High-Level Text Mining Analysis of Publications

1. Abstract 1.1. Background During the last two decades, there is a constant search for new therapeutic options for colorectal cancer (CRC). We evaluated PubMed literature on CRC different treatment options during the past two decades. Special attention was attributed to specific treatment options according to biological markers.

SARS-Cov-2: Interaction Between Mutations and Variants and Their Influence on Treatment and Preventive Strategies

1. Abstract Since the emergence of the SARS-CoV-2 induced COVID-19 pandemic, millions of patients have been diagnosed for the disease and many of them have died worldwide. SARS-CoV-2 has been undergoing genetic changes leading the disclosure of new variants. Since the unfolding of SARS-CoV-2, several recurrent mutations, particularly in the spike protein, emerge during human-to-human …

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Novel Variants Associated with Wilson Disease in Saudi Families

1. Abstract 1.1. Background: Wilson disease (WD) is an autosomal recessive inherited disorder caused by homozygous or compound heterozygous mutations in the ATP7B gene. The ATP7B gene encodes trans-membrane copper-transporting ATPase 2, which mediates the excretion of copper into bile and delivers copper to the transporting protein ceruloplasmin in blood. The genetic database reported over …

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