Research Article

Identification of Pyroptosis-Related Subtypes in Liver Cancer, Establishment of Prognostic Models, and Characterization of Tumor Microenvironment Infiltration

1. Abstract 1.1. Objectives: Pyroptosis is a type of programmed cell death that has been discovered and confirmed in recent years, which were characterized by pro-inflammatory and is related to tumor progression, prognosis and treatment response. However, the potential roles of pyroptosis-related genes (PRGs) in the tumor microenvironment (TME) remain unclear. At the same time, …

Identification of Pyroptosis-Related Subtypes in Liver Cancer, Establishment of Prognostic Models, and Characterization of Tumor Microenvironment Infiltration Read More »

Comparative Efficacy and Safety of Polyethylene Glycol vs Lactulose in Chronic Constipation: Non Inferiority Study

1. Abstract 1.1. Background: Constipation is a common condition. Lactulose & Polyethylene Glycol (PEG) are effective & safe, recommended as first-line medication for Chronic Constipation (CC). 1.2. Aim: To compare the efficacy and safety of PEG 3350 versus lactulose in patients with CC. 1.3. Methods: In this single-center, randomised, open label, parallel-group study. Patients with …

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Upper Limit of Normal Serum Alanine Transaminase ALT and Correlation with Gender and BMI

1. Abstract Alanine transaminase ALT is considered the most specific marker for hepatocellular membrane damage, once asymptomatic ALT elevation may be the only indicator of some liver diseases such as non-alcoholic fatty liver disease NAFLD which is the most common liver disease in the western world, so it is necessary to define upper limit of …

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Identification of Polyamine Subtypes in Hepatocellular Carcinoma and Characteristics of their Immune Infiltrates

1. Abstract 1.1. Background: Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related death. Due to the poor prognosis of standard treatment, it is urgent to evaluate the immune molecular characteristics and find new HCC immune biomarkers and immunotherapy . The homeostasis of polyamines is closely related to tumor progression and prognosis. The …

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Role of Immunohistochemically Typing in Pancreaticobiliary and Intestinal Type Differentiation of Periampullary Adenocarcinomas

1. Abstract 1.1. Background: Ampullary cancer is of particular classificatory interest as it may arise either from the intestinal epithelium or the epithelium covering the pancreatobiliary ducts knows as Intestinal type (IT) and Pancreatobiliary type (PBT) respectively. These 2 histological subtypes have different clinical characteristics, in terms of disease stage, recurrence rates and survival. Immuno …

Role of Immunohistochemically Typing in Pancreaticobiliary and Intestinal Type Differentiation of Periampullary Adenocarcinomas Read More »

Effective Strategies for Preventing Vertical Transmission in Hepatitis B

1. Abstract 1.1. Introduction: Hepatitis B Virus (HBV) infection is a global problem with nearly 350 million chronic carriers, who are at risk of liver cirrhosis & hepatocellular carcinoma. Over 50% of these carriers are believed to have acquired their infection vertically from their mothers, i.e. through mother – to – Child Transmission (MTCT). Vertically …

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Inflammatory Bowel Disease in a Central Rural Area, Riyadh Province Al-Kharj of Saudi Arabia: Epidemiology, Clinical Characteristics, Natural Course of Disease and Current Clinical Practice

1. Abstract 1.1. Background and Aim The epidemiology, clinical characteristics, natural course, and treatment of Inflammatory Bowel Disease (IBD) in the gastroenterology centres of Al Kharj, Riyadh Province, are still largely unknown. Therefore, a survey was conducted to describe IBD features to correlate the findings with published data from the rest of the country and …

Inflammatory Bowel Disease in a Central Rural Area, Riyadh Province Al-Kharj of Saudi Arabia: Epidemiology, Clinical Characteristics, Natural Course of Disease and Current Clinical Practice Read More »

Changes of Plasma Biomarkers in Patients with Chronic Liver Diseases Predict Liver Cell Death

1. Abstract 1.1. Background: We evaluated the changes of biomarkers and their significance in patients with nonalcoholic fatty liver disease. 1.2. Methods: One hundred and ten nonalcoholic fatty liver disease patients were enrolled into experimental group and one hundred and ten healthy people into control group. The plasma levels of biomarkers were detected. 1.3. Results: …

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