Review Article

Can combination of SGLT2 inhibitors and DPP-4 inhibitors be combination of choice for T2DM associated MAFLD?

1. Abstract Globally, metabolic associated fatty liver disease (MAFLD) is the leading cause of liver disease and the most common cause for liver transplantation. Type 2 Diabetes mellitus (T2DM) is major risk factor for development of MAFLD with Indian prevalence of 56.5% T2DM patients suffering from MAFLD. MAFLD and T2DM are pathophysiological linked with IR, …

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Expression Mechanism of Immunogenic Cell Death-Related Molecules in Colorectal Cancer

1. Abstract Immunogenic Cell Death (ICD) plays an important role in the treatment of colorectal cancer, and the relevant molecular mechanisms of its role in colorectal cancer are closely related to a variety of Damage-Associated Molecular Patterns (DAMPs), such as calreticulin (CRT), Heat Shock Protein (HSP), Adenosine Triphosphate (ATP), high mobility group protein B1 (HMGB1) …

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Role of TGF-Β in Colorectal Cancer: Mechanisms, Diagnosis and Therapies

1. Abstract Colorectal cancer (CRC) is a substantial public health challenge across the globe. Transforming growth factor-β (TGF-β) is a critical pathway in CRC that regulate numerous cellular processes, including immune-suppression, growth inhibition, cell migration, invasion, epithelial-to-mesenchymal transition and extracellular matrix remodeling. Metastasis is the major cause of death in patients with colorectal cancer. TGF-β …

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Partial Splenic Embolization for the Treatment of Thrombocytopenia in Cancer Patients

1. Abstract Thrombocytopenia is a common sequela of chemotherapy treatment of many non-hematologic malignancies. Severe thrombocytopenia may necessitate halting chemotherapy or lead to hemorrhagic complications that impact patient morbidity and mortality. Partial Splenic Embolization (PSE) has been shown to be effective at improving platelet counts in appropriately selected patients and allowing for the resumption of …

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Cancer from an Unknown Primary Source

1. Abstract The diagnosis of Cancer of Unknown Primary is difficult even in the present era of modern medicine. The incidence is closed to 2-5% of all epithelial cancers. There is no concrete explanation behind the development of these cancers, however, recent studies suggested the role of chromosomal abnormalities and neoangiogenesis in the development. Overall, …

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Non-Invasive Biomarkers of Intestinal Inflammation and Increased Gut Permeability in Inflammatory Bowel Diseases

1. Abstract Inflammatory bowel diseases (IBD) are chronic conditions of the intestine characterized by the inflammation of the gut’s wall or mucosa. Their etiology is unknown, most probably multifactorial including genetic susceptibility, dysbiosis and environmental factors. The diagnosis is based on both clinical and endoscopic features. However, recently easy, fast, reliable, and non-invasive biological markers …

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Gastrointestinal Stromal Tumors About an Epidemiological Survey

1. Abstract We carried a descriptive retrospective study over a period of 5 years from January 2016 to January 2021, in our hepato-gastroenterology department at the CHU Mohammed VI Marrakech. The aim of this study is to report on the epidemiological, clinical, histological and therapeutic characteristics of GISTs and to report the rare localizations of …

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Upper Gastrointestinal Hemorrhage: A Narrative Review

1. Abstract Upper gastrointestinal bleeding is the most common gastrointestinal emergency with a mortality rate of 2-10% reported in the literature. H. pylori and NSAID therapy are the two most common causes of upper GI bleeding. Fortunately, anti-H. pylori regimen and proton pump inhibitors respectively are the most effective strategies for the treatment of UGIB. …

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Management of Non-alcoholic Fatty Liver Disease in Adults: An update

1. Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) is an extensive term which covers a spectrum of conditions that are characterized by evidence of hepatic steatosis on imaging or histology (macro-vesicular steatosis), and absence of secondary causes of hepatic steatosis such as significant alcohol consumption, chronic use of medications that can cause hepatic steatosis or hereditary …

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Nomogram Predicting Survival After Resection of Non-Functioning Neuroendocrine Tumors of the Pancreas Based on SEER Data

1. Abstract 1.1. Background: Although Pancreatic Neuroendocrine Tumors (PNETs) are a rare form of pancreatic tumor, their incidence is on the rise. Overall survival for these patients strongly correlates to the stage at diagnosis. Other prognostic factors that may impact on survival include tumor grade and lymph node metastases. The aim of this study was …

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