Review Article

Acute Peritonitis Generalized by Typhoid Perforation at Kankan Regional Hospital

1. Abstract 1.1. Aim: The aim of this study is to make our contribution to the study of acute generalized peritonitis of typhus origin at the Kankan Regional Hospital. Typhoid perforation is defined as the opening of a hollow viscus in the abdominal cavity due to salmonella. 1.2. Methodology: We carried out a 6-month prospective …

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Immune Profile of Severe Refractory Crohn’s Disease Patients Candidates to Autologous Hematopoietic Stem Cell Transplantation

1. Abstract Crohn’s disease is a chronic relapse – remitting inflammatory bowel disease with a wide range of incapacitating symptoms, and significant health care costs. The complex pathophysiology of Crohn’s disease is not always solved by conventional and biologic therapies and thus, some patients evolve with severe refractory disease. T and B cells reacting to …

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Large Bowel Auto-Immune Diseases: Current Recommendation for Surgery

1. Abstract There are two clinical features of autoimmune disease in the large intestine that we often find in our clinical practice, including ulcerative colitis and Crohn’s Disease. The clinical picture that we need to understand is the change in bowel patterns over the past few weeks. Clinical symptoms that appear need to be diagnosed …

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Quo Vadis Medicina Ex Testimoniis? Part 2. After A Quarter of Century, What Now? Some Questions and Answers

1. Abstract Despite being a young domain with a one-generation history or so, evidence-based medicine has benefitted from thousands of contributions, as reflected in numerous book titles and subjects, and original articles. EBM-related philosophical insights are increasing as are endeavours in reasoning, modern argumentation, considerations of causality, and grading of evidence. DOI: http://dx.doi.org/10.47829/JJGH.2020.5302

Quo Vadis Medicina Ex Testimoniis? Part 1. A Quarter Century after Its Inception, Where is Evidence-Based Medicine (EBM) Today? More Questions than Answers

1. AbstractThe domain of ‘Evidence-based medicine’ (also known as ‘EBM’) is increasingly ubiquitous across the medical literature and experience. It is just about one generation old and worthy of further refinements.Five related insights are outlined here:Among others, clinical epidemiology, fundamental and field epidemiology and biostatistics have led to EBM. DOI: http://dx.doi.org/10.47829/JJGH.2020.5303

Acronymization of Evidence-Based and Other Medicines Anything Goes, or Should It?

1. Abstract Evidence-Based Medicine is here to stay, and it is expanding, with evolving modifications, new topics, new research and teaching groups, and new recipients of information. Acronyms, as brief and condensed ways to present and understand ideas related to the above-mentioned phenomena, are also increasing in number and some, serious or funny, are worthy …

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Quo Vadismedicina Ex Testimoniis? A Quarter Century after its Inception, Where is Evidence-Based Medicine Now? More Questions than Answers

1. AbstarctTo mistrust science and deny the validity of the scientific method is to resign your job as a human. You’d better go look for work as a plant or wild animal. P.J. O¬íRourke 1947- Parliament of Whores (1991).Just as Peter asked Jesus in the New Testament about two thousand years ago, Domine, quo vadis? …

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Putative Regulatory Element Located in the Introns 9 and 17 of the ACE2 Gene May Be Influenced By COVID-19 Risk Variants

1. Abstract Preliminary genomic data of the SARS-CoV2 virus responsible for COVID-19 showed that, its ability to infect relies on special cell surface spike proteins that have binding affinity to the human protein angiotensin-converting enzyme (ACE2). Among several patients analysed, it usually infects most age groups evenly. However, only a small percent of the confirmed …

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