Volume 1

A Giant Simple Hepatic Cyst with Chronic Constipation

Clinical Image

Hepatic cysts are abnormal fluid-filled spaces in the hepatic parenchyma and biliary tract. The cysts usually are asymptomatic and as a casual finding during the general health check-up and screening imaging examinations. Simple hepatic cysts are known to be congenital in origin, the most common benign tumors of the liver and

Intrahepatic Cholestasis and Fetal Demise: Association or Causation?

Review Article

Data are conflicting regarding a cause and effect relationship between ICP and stillbirth. On one hand, the data show a higher risk of stillbirth at term without an effective test that might predict demise except high level of bile acids. On the other, even if the stillbirth rate is reduced by a late preterm birth, one must appreciate the cost of active

The Gastric Tumor That Wasn’t There

Clinical Image

32-year-old female was admitted to the hospital with epigastric abdominal pain, nausea, vomiting with a band like distribution. She reported longstanding pain that has progressively worsened in the last two months, with unintentional weight loss of 12 pounds, diminished appetite, and nausea

Prognosis and Treatment Strategy of Early Gastric Cancer with Signet Ring Cell Histology


The prognosis of early gastric cancer (GC) with signet ring cell (SRC) histology comparing with other subtypes remains a matter of debate. Kim et al. indicated that early GC with SRC differs clinical course and prognosis from non-SRC.1 They found that mucosal and submucosal GC with poor differentiation had 6.3% and 30% of lymph node metastasis, respectively

Take Constipation Appendix Disease Seriously

Review Article

To pay attention to the “constipation appendicitis”, and to explore the clinical management strategy of reoperation due to the misdiagnosis of intractable constipation appendicitis

Personalized Evidence-Based Medicine in Need of High-Quality Data

Short Communication

The truth in medicine does not exist, since 3500 publications are added every day to the knowledge base of medicine[1]. Each day the truth changes a little. Today, evidence-based medicine with its key methodology of systematic reviews of randomized controlled trials attempts to sift out the valuable ‘true’ information[2]

Therapeutic Drug Monitoring of Thiopurine Therapy in Patients with Inflammatory Bowel Disease

Review Article

The number of patients with inflammatory bowel disease (IBD) is increasing in the worldwide. Thiopurine S-methyltransferase (TPMT) plays a significant role in the metabolism of thiopurine drugs

The Need of CDH1 Germline Mutation Screening in Patients with Gastric Cancer in the West

Research Article

Although the international guidelines recommend the CDH1 germline mutations screening in patients at risk of carrying pathogenic mutations, few data exist about the compliance to systematic screening programs carried out in surgical centres

New Factors in Screening Colonoscopy for Colorectal Neoplasia

Short Communication

Colonoscopy screening for colorectal adenomatous polyps or cancer has become a worldwide recommendation since this is the third most common human cancer[1-3] resulting in an estimated 49900deaths annually[3]. Furthermore, polyps and cancers have been observed in younger people resulting in recommendations by societies to start screening at age 45 [4].

Volumetric-Based Analysis of In-Vivo and Ex-Vivo Quantita-tive MR Diffusion Parameters in Pancreatic Adenocarcinoma: Correlation with Pathologic Findings

Research Article

Imaging biomarkers are needed to assess modifications in pancreatic adenocarcinoma (PA) induced by stroma-targeted therapies. The study investigates correlations between quantitative diffusion parameters obtained in vivo and ex vivo with a tumour volumetric approach and quantitative pathologic findings including fibrosis, vascular and total nuclear densities in PA