Issue 4 Articles

Prevalence of Nocturnal Leg Cramps in Patients with Liver Disease is Higher than with Other Chronic Disease

Research Article

A nocturnal leg cramps (NLC) is caused by a continuous, involuntary, painful, and localized contraction of a muscle or simply some muscle bundles.NLC is associated with a reduced quality of sleep and a subsequent lower health related quality of life. The purpose of our study is to clarify both prevalence and characteristics of NLC in patients with chronic diseases….

The Relationship between Pancreatic Fibrosis and Pancrea- tic Cell Apoptosis Induced by Fas/Fas Ligand Pathways in Aly/Aly Mice

Research Article

In this study, we examined the relationship between the expression of Fas/Fas ligand apoptotic signaling pathway and pancreatic fibrosis in autoimmune chronic pancreatitis of aly/aly mice. The histopathological changes of inflammatory cell infiltration in pancreatitis aly/ aly mice were observed. Immunohistochemistry was used to detect the expression of CD4, CD8, CD45R/B220, F4, Fas/Fas ligand, collagen I, TGF-? and a-SMA in pancreatic tissues….

The Endoscopic Combo Technique: Long-Term Outcomes in Treating Patients with Primary Achalasia

Research Article

Achalasia is a primary esophageal motility disorder characterized by the absence of esophageal peristalsis and impaired relaxation of the Lower Esophageal Sphincter (LES) in response to swallowing. The annual incidence of achalasia is approximately 1.6 per 100,000 individuals worldwide and prevalence of 10 cases per 100,000 individuals. Patients present usually with progressive dysphagia to solids and liquids, regurgi- tation, heart burn, chest pain…

Surveillance of COVID-19 Patients with Pre-Existing Liver Diseases: Need to Address

Rapid Communication

Nearly 60% of the patients with the novel virus have elevated liver enzymes. Liver inflammation can be hypothesized to the immune mediated process such as cytokine storm and pneumonia associated hypoxia that may lead to liver enzyme abnormalities or liver failure in critically ill patients…

Quadruple with Omeprazole, Bismuth, Tetracycline and Metroni- dazole Therapy for the Eradication of Helicobacter Pylori: Efficacy in Naive and Previously Treated Patients with Double and Triple Antimicrobial Resistance

Research Article

To eradicate Helicobacter Pylori (HP) infection it’s necessary to use at least two antibiotics. In patients infected with HP resistant to two or three antibiotics, eradication is more difficult. The objective of this study was to evaluate the efficacy of bismuth quadruple therapy (BQT)-10 days (omeprazole, bismuth, tetracycline-TET, and metronidazole-MTZ) for the eradication for HP in naïve and previously treated patients