Volume 6

Long-Term Outcomes of Endoscopic Treatment for Bile Duct Stones in Patients Aged ≥ 85 Years

Research Article

1. Abstract

1.1. Aims: There are limited data regarding the safety and efficacy of complete stone removal for the treatment of bile duct stones in elderly patients. Hence, this study evaluated the long-term outcomes of complete stone removal in elderly patients.

DOI:http://dx.doi.org/10.47829/JJGH.2021.62203

The Use of Inhalational Nitrous Oxide (Entonox) As The Sole Analgesic Agent During Colonoscopy is Feasible and Efficacious in a Substantial Proportion of Patients: A Review of a Surgeon’s Experience

Research Article

1. Abstract

1.1. Objective: Colonoscopy is associated with significant discomfort requiring administration of intravenous (IV) sedation and analgesia. Nitrous Oxide (Entonox) has been shown as an alternative analgesic modality but is less frequently used in practice. This study examined the efficacy and applicability of Entonox as sole analgesic agent during colonoscopy.

DOI:http://dx.doi.org/10.47829/JJGH.2021.62202

Synthesis, Characterization, Biological Evaluation of Some Heterocyclic Oxazepine Derivatives

Research Article

1. Abstract

The new serious of pentyloxy and aryloxy benzaldehyde (3ae) were synthesized from the substitution reaction of 4-hydroxy benzaldehyde with different aryl bromide and alkyl bromide, on the basis of Williamson ether synthesis in the presence of Potassium carbonate using absolute ethanol as a solvent. The second step was the synthesis of 2-amino-5-(p-tolyl)1,3,4-thiadiazole.

DOI:http://dx.doi.org/10.47829/JJGH.2021.62201

Mixing of Sputnik V and Astrazeneca COVID-19 Vaccines

Research Article

1. Abstract

The coronavirus disease 2019 (COVID-19) vaccine helps to develop immunity to SARS-CoV-2, the virus that causes COVID-19, in most cases preventing the disease. Although various brands of vaccines work in different modes, all
COVID-19 vaccines prompt an immune reaction to make the body remembers how to protect from the virus in the future. The present study aims to evaluate the safety and the immune response for mixing of Sputnik V and AstraZeneca COVID-19 vaccines on mice.

Epidemiology of Hepatocellular Carcinoma (HCC) In Tertiary Level Hospitals in Bangladesh

Case Report

1. Abstract

HCC is the most common primary liver malignancy and cause of cancer-related death worldwide including Bangladesh. It occurs more often in males than females. The incidence of HCC continues to escalate due to HBV, HCV infection, non-alcoholic fatty liver disease (NAFLD). HBV and HCV are also important etiological factors for developing chronic liver disease (CLD) and HCC.

BRAF p. V600E Mutation as Acquired Resistance Mechanism of Lorlatinib in a ROS1 Rearrangement Lung Adenocarcinoma Patient with Liver Metastasis with Primary Ceritinib Resistance

Case Report

1. Abstract

Both crizotinib and ceritinib are recommended as first-line therapy for NSCLC with ROS1 rearrangements, with the latter having stronger infiltration ability across blood-brain barrier. Here we report for the first time that a brain metastatic adenocarcinoma patient with CD74-ROS1 rearrangement was sensitive to crizotinib but resistant
to ceritinib. Intracranial progression happened after 7 months of crizotinib, and sencond-line lorlatinib resulted in partial response and a PFS of 8 months. Upon lorlatinib resistance, repeated NGS detection of ctDNA from peripheral blood showed BRAF p. V600E, CD74-ROS1 and ROS1 pG2032R.

DOI:http://dx.doi.org/10.47829/JJGH.2021.62105

Hydrocolonic Sonography. A Forgotten Technique

Review Article

1. Abstract

1.1. Objectives: Study of the sensitivity of Hydrocolonic Sonography (HS) in the detection of colonic lesions and how hydrocolonic sonography with echographic contrast agent (HSEC) can improve this technique.

Hydrocolonic sonograhpy with ultrasound contrast (dual system), of a malignant polyp in sigmoid colon. On the left half of the video, we can observe a 35 mm lesion which is strongly and evenly enhanced from the 25 second mark until the end of the video. Faecal remains appear as hyperechoic images that do not show contrast.

Exploration of the splenic angle and upper portion of the descending colon using contrast. On the left, in contrast mode. In the left half, the enhanced lesion has a central area where the saline solution does not show contrast. This behaviour gives it the characteristic “inverted apple core” appearance of an adenocarcinoma, which can be seen in the first 20 seconds and after the 50 seconds mark until the end of the video. However, in the second period the enhancement is lower. In the right half, the hypoechoic lesion can be seen without enhancement. Note how linear the wall is without lesions in both halves. Faecal remains appear as hyperechoic images which move with the serum.

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DOI:http://dx.doi.org/10.47829/JJGH.2021.62104

Increased Expression of GNL3L is Associated with Aggressive Phenotypes in Colorectal Cancer

Research Article

1. Abstract

1.1. Background and Objective: Guanine nucleotide binding protein-like 3-like (GNL3L) plays critical roles in development and progression of several types of human cancers. However, the function and clinical significance of GNL3L in colorectal cancer (CRC) remain unclear. In this study, the effect of GNL3L in CRC and its underlying mechanism were investigated.

DOI:http://dx.doi.org/10.47829/JJGH.2021.62103

Autologous Marrow Intrahepatic Infusion Promotes Immune Reconstruction in AIDS Patients

Case Report

1. Abstract

AIDS late immune function is low, prone to a variety of opportunistic infections. The application of antiviral drugs, anti-tuberculosis drugs and other treatments may cause liver damage, and further aggravate the immunodeficiency.

DOI:http://dx.doi.org/10.47829/JJGH.2021.62102

Liver Transplantation Technique from A Cadaveric Donor with Situs Inversus Totalis. Review and a New Case

Case Report

1. Abstract

Because of the shortage of organs available for transplantation, bodies that may be valid, such as those coming from donors with situs inversus totalis, should not be ruled out.

DOI:http://dx.doi.org/10.47829/JJGH.2021.62101