Volume 6

Epidemiology of Hepatocellular Carcinoma (HCC) In Tertiary Level Hospitals in Bangladesh

Case Report

1. Abstract

HCC is the most common primary liver malignancy and cause of cancer-related death worldwide including Bangladesh. It occurs more often in males than females. The incidence of HCC continues to escalate due to HBV, HCV infection, non-alcoholic fatty liver disease (NAFLD). HBV and HCV are also important etiological factors for developing chronic liver disease (CLD) and HCC.

BRAF p. V600E Mutation as Acquired Resistance Mechanism of Lorlatinib in a ROS1 Rearrangement Lung Adenocarcinoma Patient with Liver Metastasis with Primary Ceritinib Resistance

Case Report

1. Abstract

Both crizotinib and ceritinib are recommended as first-line therapy for NSCLC with ROS1 rearrangements, with the latter having stronger infiltration ability across blood-brain barrier. Here we report for the first time that a brain metastatic adenocarcinoma patient with CD74-ROS1 rearrangement was sensitive to crizotinib but resistant
to ceritinib. Intracranial progression happened after 7 months of crizotinib, and sencond-line lorlatinib resulted in partial response and a PFS of 8 months. Upon lorlatinib resistance, repeated NGS detection of ctDNA from peripheral blood showed BRAF p. V600E, CD74-ROS1 and ROS1 pG2032R.

Hydrocolonic Sonography. A Forgotten Technique

Review Article

1. Abstract

1.1. Objectives: Study of the sensitivity of Hydrocolonic Sonography (HS) in the detection of colonic lesions and how hydrocolonic sonography with echographic contrast agent (HSEC) can improve this technique.

Recent Insights in Hepatic Encephalopathy: A Review Article

Review Article

1. Summary

1.1. Background: Hepatic Encephalopathy (HE) is an unfavorable neurological consequence of Decompensated Chronic Liver Diseases (DCLD). HE is associated with high fatality rate and undesirable impact on different aspects of quality of life (QOL).

Increased Expression of GNL3L is Associated with Aggressive Phenotypes in Colorectal Cancer

Research Article

1. Abstract

1.1. Background and Objective: Guanine nucleotide binding protein-like 3-like (GNL3L) plays critical roles in development and progression of several types of human cancers. However, the function and clinical significance of GNL3L in colorectal cancer (CRC) remain unclear. In this study, the effect of GNL3L in CRC and its underlying mechanism were investigated.

Autologous Marrow Intrahepatic Infusion Promotes Immune Reconstruction in AIDS Patients

Case Report

1. Abstract

AIDS late immune function is low, prone to a variety of opportunistic infections. The application of antiviral drugs, anti-tuberculosis drugs and other treatments may cause liver damage, and further aggravate the immunodeficiency.

Liver Transplantation Technique from A Cadaveric Donor with Situs Inversus Totalis. Review and a New Case

Case Report

1. Abstract

Because of the shortage of organs available for transplantation, bodies that may be valid, such as those coming from donors with situs inversus totalis, should not be ruled out.

Review of Esophagectomy Side Effects

Research Article

1. Abstract

The primary indication for an esophagectomy is esophageal cancer or Barrett’s esophagus with high-grade dysplasia. Patients undergoing esophagectomy often present with dysphagia, side effects from chemotherapy, decreased appetite, and weight loss. Esophagectomy may be an operation involving the abdomen, neck, and/or chest requiring 5 to 7 days of NPO status to permit healing of the anastomosis between the upper esophagus and new esophageal conduit (usually the stomach).

Need of Dual Antiviral Treatment in Chronic Hepatitis B

Research Article

1. Abstract

1.1. Introduction: Approximately one third of the world’s population has serological evidence of past or present infection with the hepatitis B virus (HBV). An estimated 350-400 million people are surface HBV antigen (HBsAg) carriers. India has 40 million HBV carriers i.e. 10–15% share of total pool of HBV carriers of the world. In India.

Endoscopic Ultrasound – Guided Gastrojejunostomy Stent Placement – A Novel Technique to Manage Afferent Loop Syndrome

Original Article

1. Abstract

Afferent Loop Syndrome (ALS) is a complication caused by obstruction of the biliopancreatic limb after gastrointestinal reconstruction. Re-operation is preferred in surgically fit patients, but higher-risk patients have limited surgical options. We present a case of ALS secondary to duodenal cancer recurrence after a Whipple procedure, treated successfully with the novel endoscopic ultrasound-guided gastrojejunostomy stent placement (EUS-GJ).