Volume 8

Diagnosis At First Sight: Fish-Eye Ampulla

Clinical Image

1. Clinical Image

A 62-year-old woman is presented with nausea, vomiting, abdominal pain, fever, and pale color of defecation for one week. She denied other gastrointestinal symptoms. Physical examination was unremarkable. Laboratory tests showed the following abnormal tests: SGPT: 131 U/L, SGOT: 56 U/L, ALP: 575 U/L, GGT: 911 U/L, Total bilirubin: 10,4 mg/dL, direct bilirubin: 8,5 mg/dL, Leukocyte count: 16400/uL, CRP: 134 mg/L. Magnetic resonance cholangiopancreatography showed dilated intrahepatic bile ducts, hydropic gall bladder, and sludge. The common bile duct was 20 mm. Endoscopic retrograde cholangiopancreatography (ERCP) showed fish-eye sign and viscous fluid flow in the papilla (Figure 1).

Efficacy of Pemafibrate Against Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study

Research Article

1. Abstract

1.1. Background: Nonalcoholic fatty liver disease (NAFLD), one of the most common causes of chronic liver diseases, is characterized by chronic liver inflammation and fibrosis, which consequently promote cirrhosis and liver cancer. Pemafibrate, a selective PPARĪ± modulator is a new lipid-lowering drug that provides better hypertriglyceridemia control compared to greater other fibrates without increasing adverse effects.

Treatment Protocol of the Most Common Anorectal Pathologies with Association between Micronized Purified Flavonoid Fraction and Sucralfate for Local Application

Review Article

1. Summary (Aim)
The author proposes to test the effectiveness of the combined action of
1- Micronized Purified Flavonoid Fraction – MPFF
associated with topical action “barrier effect” of
2 – Sucralfate (as SOS – Sucralfate Ointment with Soothing Herbs) for some of the most common anal
pathological situations with two main objectives:

Immunological Reason for Mild Affection of Children to COVID-19, A Key Factor for Novel Solution of Vaccination and Medications

Research Article

1. Abstract

Coronaviruses are important human and animal pathogens. We will show that probably antibodies don’t have essential role in immunity against COVID-19 in long term, but a type of white globules named T cells may have critical role in immunity against COVID-19. T cells have long time memory to remain in blood.

Anesthetic Management for Patients With Pheochromocytoma : Series of Three Cases

Case Report

1. Abstract

1.1. Background. This study describes a case series that addresses the complex anesthetic management of adrenalectomy for patients with pheochromocytoma. It is a rare tumor, originating in the chromaffin cells of the adrenal medulla and a catecholamine-secreting agent, whose most common triad of symptoms is headache, sweating and tachycardia.

Microrna-145 Inhibits EMT and Fibrosarcoma Cell Proliferation, Migration and Invasion by Targeting HMGA2

Research Article

1. Abstract

1.1 Aim: Fibrosarcoma is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth and a high rate of local recurrence. The participation of microRNAs (miRNAs/miRs) in the pathogenesis of human diseases and the vital role of miR-145 in different types of cancer. However, the role of miR-145 in fibrosarcoma remains unclear.

Primary Biliary Cholangitis and Type 1 Diabetes in A Male Patient: A Case Report

Case Report

1. Abstract

Primary Biliary Cholangitis (PBC) isa cholestatic disease of autoimmune origin characterized by the destruction of small to medium size intrahepatic bile ducts due to lymphocytic infiltration. The diagnosis is made by the presence of Anti-Mitochondrial Antibodies (AMAs) specific for the disease. PBC typically affects middle-aged women and is often associated with other autoimmune pathologies which are in decreasing order of frequency: Sjogren’s syndrome, autoimmune dysthyroidism, scleroderma, rheumatoid arthritis, lupus and celiac diseasewhich are also more common in women.

Pseudotumoral Form of Primary Hepatic Tuberculosis: A Rare Case Report with Review of the Literature

Case Report

1. Abstract

The isolated location of tuberculosis is very rare constituting less than 1% of all locations. We report through this observation the case of a 23-year-old patient, who complains of chronic pain in the right hypochondrium in a context of deterioration of the general condition. The biological assessment showed a biological inflammatory syndrome. A thoracic-abdominal-pelvic computed tomography (CT) showed an enlarged liver, with regular contours and multiple hypodense nodular formations.

Comparing The Efficacy and Safety of Local-Regional Treatments for Hepatocellular Carcinoma with Portal/Hepatic Vein Tumor Thrombosis in China: A Network Meta-Analysis of Randomized Control Trials

Review Article

1. Abstract
1.1. Purpose: We assessed the efficacy and safety of different local-regional regimens using the network metaanalysis
for hepatocellular carcinoma (HCC) with portal/hepatic vein tumor thrombosis. The interested modalities included neoadjuvant three-dimensional radiotherapy(3D-CRT), postoperative intensity-modulated radiation therapy(IMRT), Postoperative transarterial chemoembolization (TACE), 3DCRT plus TACE, and Surgery alone.